Research team includes research fellows, research nurses and several
collaborators.
Please select from the following topics:
Prostate
Participant in multi-centre study of transurethral vaporisation of prostate
(TVP) versus transurethral resection of prostate (TURP) 1998-2000. Funded
by NHS health technology assessment
TUNA. Contributing data into the European Association of Urology Central
Registry 2004 - ongoing. Only UK contributor
Prostate Cancer in Ethnic Subgroups (PROCESS) - Incidence, presentation and
access to health care. I am a co-recipient of a grant from the Department of
Health. It is previewed on BBC online. The study commenced in 2003. Study
centres in London and Bristol. Accepted for publication 2007
Ethnicity and prostate cancer in East London. I have published the first UK
data (abstract 2003, full paper December 2006) demonstrating an increased incidence of prostate cancer in
black men in a UK population. Work is ongoing
Prognostic factors in prostate cancer patients treated by watchful waiting.
A joint study between Memorial Sloan Kettering Institute in New York and
various UK institutions. 1999 - ongoing. This will lead to better
identification of those men who can be safely kept under "watchful waiting"
rather than undergo radical treatment for prostate cancer
Intermittent hormone therapy with immediate versus deferred
radiation localised prostate cancer. Lead clinician and
originator for this Barts and The London study. Six years into a 10 year study
European study [SEUG9001] into intermittent androgen suppression in prostate
cancer
Phase 2 study of safety and tolerability of FE200486 (LHRH antagonist) in
prostate cancer. Completed 2003
Dutasteride versus placebo for 4 years to reduce risk of biopsy detected
prostate cancer. I am actively recruting into this study. It is for men
with suspected prostate cancer but with a negatiave biopsy. Research
suggest that 30% may subsequently be diagnosed with prostate cancer. The
study is to find out if the drug dutasteride can reduce this risk. It is a
multi-centre International study
Mitoxantrone and prednisolone and YM598 or placebo in hormone refractory
prostate cancer. 2003. Recruitment complete
Lamins, capsaises and granzyme in prostate cancer. Supported by Cancer
Research Fund Barts and The London. Work completed 2004 by my research
registrar for MD thesis. Joint supervision with histopathology
P1NP versus bone scan in the staging of prostate cancer. 2002-04. Can
a simple, cheap blood test replace bone scanning? Work published.
Gene therapy for prostate cancer, 2005-2007. A
collaboration with Institute of Cancer Research, Charterhouse
Square, London. Work presented at National and International
meetings. Thesis submitted 2007 by research fellow (Mr
Radhakrishnan) under my supervision for a MS degree from
University of London.
The role of gonadotropins in the
development of prostate cancer. Work published and
presented at International meetings. Thesis submitted 2006
by research fellow (Mr Thwaini), under my supervision, for MS
degree from University of London
Erectile dysfunction
2mg verus 3mg Uprima in erectile dysfunction. 2003. completed.
Tadalafil versus sildenafil in the oral treatment of erectile dysfunction.
2003. Recruitment complete. A head to head study of the leading oral
treatments
Female urology
Duloxetine versus placebo in the treatment of predominant stress urinary
incontinence. 2004-2005. I actively recruited into this study.
This is the first drug for stress incontinence. Multi-centre international study.
The drug has now been launched.
Imaging
Virtual cystoscopy. This study is completed. It investigated
using CT and 3-D reconstruction to image the bladder. Work has
been presented at a National meeting and has been published.
Bladder cancer
Liarazol in superficial bladder cancer. 1998-2000. Completed.
